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by Francesco M. Rossi
The immunohistochemical expression of the NTs nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and the associated receptors p75, TrkA and TrkB was examined in the knee joint of arthritic and healthy mice. Immunoreactions for NGF and BDNF were.
The immunohistochemical expression of the NTs nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and the associated receptors p75, TrkA and TrkB was examined in the knee joint of arthritic and healthy mice. detected in cells and nerve fiber varicosities in the inflammatory infiltrates of the synovial tissue of arthritic joints but not in synovial tissue of controls. p75-immunoreactive nerve fiber-like strands were detected in inflammatory infiltrates
Neuronal plasticity is the term generally used to describe a great variety of changes in neuronal structure and functions, in. .Publications of the Scuola Normale Superiore.
Neuronal plasticity is the term generally used to describe a great variety of changes in neuronal structure and functions, in particular activity-dependent, prolonged functional changes, accompanied by corresponding biochemical and possibly morphological alterations. The first insights about. A study on nerve growth factor (NGF) receptor expression in the rat visual cortex: possible sites and mechanisms of NGF action in cortical plasticity.
In 6-month-old anti-NGF mice, we show that the reduction in cholinergic innervation of the cortex is associated with different forms of synaptic plasticity impairment. A local, acute increase in the availability of acetylcholine rescues these synaptic plasticity deficits, thus indicating that a cholinergic system mediates the impairment of cortical plasticity at this early stage of the neurodegenerative process triggered by NGF neutralization. Our results represent an important step in unveiling the pivotal role of cholinergic transmission in modulating adult cortical plasticity.
Nerve growth factor stimulates growth of cortical pyramidal neurons in young adult rats. Expression of the transcription factor Zif268 in the visual cortex of monocularly deprived rats: effects of nerve growth factor. Neuroscience, Vol. 91, Issue.
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Nerve growth factor (NGF) is the founding member of the neurotrophins, a family of secreted growth factors responsible for the growth, survival, and developmental plasticity of neuronal populations in the vertebrate peripheral and central nervous system.
neurotrophic factor (BDNF) and nerve growth factor (NGF) in the cortex.
Northern blots and polymerase chain reaction revealed the expression of neurotrophin 4 (NT4), neurotrophin 3 (NT3), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the cortex. To narrow down on the producing cell types, we quantified by reverse rase chain reaction (RT-PCR) the developmental changes of BDNF, NT3, NT4, NGF and TrkB mRNA expression in total visual cortex lysates, and in the cortical layers dissected by tangential cryostat sectioning. We found dramatic changes in laminar expression of NT3 and NGF, mild changes of NT4, and no changes of BDNF and TrkB mRNA.
Within the cortex, nerve growth factor (NGF) mediates the innervation of.Nerve growth factor-expressing neurons were observed throughout all cortical layers.
Within the cortex, nerve growth factor (NGF) mediates the innervation of cholinergic neurons during development, maintains cholinergic corticopetal projections during adulthood and modulates cholinergic function through phenotypic control of the cholinergic gene locus. As cortical expression of the NGF receptors TrkA and p75 are confined to cholinergic corticopetal fibers, the observed labeling of NGF is unlikely to reflect endocytosed NGF, but instead is indicative of NGF-producing cells (Holtzman et a. 1995; Rossi et a. 2002; Stephens et a. 2005).
We investigated whether nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) can modulate the release of neurotransmitter in the rat visual cortex at the peak of the critical period for plasticity (P23). The release of glutamate, acetylcholine and gamma-aminobutyric acid (GABA) from visual cortical synaptosomes was analysed in continuous perfusion conditions. We found that NGF enhances the d release of glutamate (approximately 90%) and acetylcholine (approximately 35%) but not that of GABA
Neurotrophins are important regulators of visual cortical plasticity
Neurotrophins are important regulators of visual cortical plasticity. Rats were monocularly deprived for 1 week at the peak of the critical period, and neurotrophins were infused intracortically. It has been recently shown that neurotrophins, neurotrophic factors of the nerve growth factor (NGF) family (Levi-Montalcini, 1987; Lewin and Barde, 1996), have an important role in neural activity-dependent development and plasticity of the brain and in particular of the neocortex (Thoenen, 1995; Bonhoeffer, 1996; Cellerino and Maffei, 1996; Pizzorusso and Maffei, 1996).