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by Harry Salem,Sidney A. Katz

  • ISBN: 0896037878
  • Category: Other
  • Author: Harry Salem,Sidney A. Katz
  • Subcategory: Medicine & Health Sciences
  • Other formats: docx doc lrf docx
  • Language: English
  • Publisher: Humana Press; 1999 edition (July 2, 1999)
  • Pages: 262 pages
  • FB2 size: 1871 kb
  • EPUB size: 1438 kb
  • Rating: 4.3
  • Votes: 869
Download Toxicity Assessment Alternatives: Methods, Issues, Opportunities fb2

Methods, Issues, Opportunities About this book.

Methods, Issues, Opportunities. This book is an up-to-date description of what has been accomplished thus far in developing acceptable alternatives to classical animal toxicity assessment methods.

Автор: Salem Harry, Katz Sidney A. Название: Toxicity Assessment Alternatives .

Toxicity Assessment Alternatives book. Goodreads helps you keep track of books you want to read. Start by marking Toxicity Assessment Alternatives: Methods, Issues, Opportunities as Want to Read: Want to Read saving. Start by marking Toxicity Assessment Alternatives: Methods, Issues, Opportunities as Want to Read: Want to Read savin. ant to Read.

Then the book covers methods based on the mechanisms of eye irritation at the ocular surface, dermal toxicity testing . Finally the book presents recent innovations in alternatives, including the use of archival data, and in silico techniques.

Then the book covers methods based on the mechanisms of eye irritation at the ocular surface, dermal toxicity testing, and assessing neurotoxicity.

Additional resources for Toxicity Assessment Alternatives: Methods, Issues, Opportunities. Tative effects were seen in both the slice and microsomal investigations. This correlation showed that the slice system responds in a manner similar to that in alternative in vitro techniques.

II. Katz, Sidney A. Ill. Animal test alternatives.

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Harry Salem is the Chief Scientist at the . Army Edgewood Chemical Biological Center. Sidney A. Katz is a professor of chemistry at Rutgers University

Harry Salem is the Chief Scientist at the . He has been a visiting professor at Drexel University, Rutgers University, Temple University, and the University of Pennsylvania and he has held a variety of positions in the pharmaceutical industry and in commercial toxicology laboratories. Katz is a professor of chemistry at Rutgers University. duPont de Nemours and Company and with the . Hollingshead Corporation.

Toxicity Assessment Alternatives: Methods, Issues, Opportunities contains a broad array of critical surveys, contributed by active and respected investigators, describing their research and offering updates on toxicity assessment alternatives, directions determined by current and future grant programs, opportunities for mechanistically based test methods to detect endocrine disruptor activity, the use of alternatives in the Department of Defense hazard assessment initiatives, and the issues and opportunities for validation and regulatory acceptance. Several of these advances make use oftransgenic models that reduce the time and cost of carcinogenicity testing. Others use tissue cultures for the assessment of endocrine disrupting chemicals. Cultures of human epidermal keratinocytes are applicable as models for sulfur mustard lesions, and in vitro protein denaturation is used as a chemical test for assessing the ocular and dermal irritation potential of cosmetic prod­ ucts. Molecular modeling is applied to explaining chemical toxicity. Commercially developed assay systems have undergone extensive evaluation by their manufacturers. Some of these await external valida­ tion, and others await acceptance by North American and European regulatory agencies. Toxicity Assessment Alternatives: Methods, Issues, Opportunities provides information from members of the scientific and regulatory communities on what has been achieved and what has been accepted in alternatives to animal testing.

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