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by Esther Buytaert

  • ISBN: 9058675882
  • Category: Medical Books
  • Author: Esther Buytaert
  • Subcategory: Medicine
  • Other formats: azw txt lit doc
  • Language: English
  • Publisher: Leuven Univ Pr (May 30, 2007)
  • Pages: 144 pages
  • FB2 size: 1533 kb
  • EPUB size: 1708 kb
  • Rating: 4.6
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Download Molecular Signaling in Photodynamic Therapy: Cell Death Mechanisms & Gene Expression Analysis (Acta Biomedical Lovaniensia) fb2

In photodynamic therapy (PDT) a sensitizer, light and oxygen are used to induce death of tumor cells and in the treatment of certain noncancerous conditions.

In photodynamic therapy (PDT) a sensitizer, light and oxygen are used to induce death of tumor cells and in the treatment of certain noncancerous conditions. Cell death in PDT may occur by apoptosis or by necrosis, depending on the sensitizer, on the PDT dose and on the cell genotype. Some sensitizers that have been used in PDT are accumulated in the mitochondria, and this may explain their efficiency in inducing apoptotic cell death, both in vitro and in vivo

Cellular and molecular photodamage mechanisms are initiated by light-activation of a photosensitizer following its accumulation in cellular targets. While lethal doses of photodynamic therapy (PDT) eliminate vessels and cells, sublethal effects occur, .

Cellular and molecular photodamage mechanisms are initiated by light-activation of a photosensitizer following its accumulation in cellular targets. during fluorescence diagnosis (FD). Accordingly, the events subsequent photoactivation lead to different cellular endpoints being primarily growth stimulation, damage repair, autophagy, apoptosis, and necrosis. Activation of survival pathways seems to be not only involved in growth stimulation, but also in PDT damage transmission.

Photodynamic therapy (PDT) is a novel cancer treatment based on the tumor-specific accumulation of a photosensitizer .

Photodynamic therapy (PDT) is a novel cancer treatment based on the tumor-specific accumulation of a photosensitizer followed by irradiation with visible light, which induces selective tumor cell death via production of reactive oxygen species. To elucidate the underlying mechanisms, microarray analysis was used to analyze the changes in gene expression patterns during PDT induced by various photosensitizers. Cancer cells were subjected to four different ated PDT and the resulting gene expression profiles were compared.

In photodynamic therapy (PDT) a sensitizer, light and oxygen are used to induce death of tumor cells and in the . Some sensitizers that have been used in PDT are accumulated in the mitochondria, and this may explain their efficiency in inducing apoptotic cell death, both in vitro and in vivo

cle{, title {Molecular mechanisms of photodynamic therapy.

The availability of multiple PS with different structures and functional properties makes PDT an extremely versatile and, conversely, a challenging approach to cancer therapy. cle{, title {Molecular mechanisms of photodynamic therapy. author {Bernhard Ortel and Christopher R. Shea and P G Calzavara-Pinton}, journal {Frontiers in bioscience}, year {2009}, volume {14}, pages {.

Molecular Signaling in Photodynamic Therapy: Cell Death Mechanisms & Gene Expression Analysis (Acta Biomedical .

Molecular Signaling in Photodynamic Therapy: Cell Death Mechanisms & Gene Expression Analysis (Acta Biomedical Lovaniensia) EAN 978905867. 00 руб. Life-cycle of Npp2, a Lysophospholipase D (Acta Biomedical Lovaniensia) EAN 978905867. 26 руб. Function & Regulation of the Reversible Methylation of Protein Phosphatase 2a (Acta Biomedical Lovaniensia) EAN 978905867.

the mechanisms involved in cell killing after photodynamic treatment. Figure 1: The mechanism of PhotoDynamic Therapy action on cancer cells. Upon irradiation with visible light of a specific wavelength, the Photosensitizer (PS) is excited from a ground state to an excited state, which transfers its energy to tissue ground state triplet oxygen producing singlet oxygen (1O2), a very reactive chemical specie able to destroy a tumour by multifactorial mechanisms.

Cluster analysis of five different time point gene expressions compared with control. We found that cell death caused by HY-PDT therapy was caused by caspasedependent apoptosis. The full heat map for the unsupervised clustering of CNE-2 lines, with the indicated time points. Each horizontal row indicates a single time point gene expression from the indicated treatment group. Caspase-dependent apoptosis signaling pathways have been found in two forms: nt (intrinsic signal) and extrinsic signal (such as tumor necrosis factor and Fas ligand)-dependent.

Keywords: photodynamic therapy; cell death; apoptosis; necrosis; autophagy; cancer Cancers 2011, 3 2517 1. Introduction Photodynamic therapy (PDT) is a promising therapeutic procedure for the management of a variety of solid tumors and non-malignant lesions

Keywords: photodynamic therapy; cell death; apoptosis; necrosis; autophagy; cancer Cancers 2011, 3 2517 1. Introduction Photodynamic therapy (PDT) is a promising therapeutic procedure for the management of a variety of solid tumors and non-malignant lesions

We started to apply photodynamic therapy with use of Radahlorin for the enhancement of the results of treatment of recurrent basal cell . Фотодинамическая терапия в комбинированном лечении больных немелкоклеточным раком легкого: автореф.

We started to apply photodynamic therapy with use of Radahlorin for the enhancement of the results of treatment of recurrent basal cell skin cancer. New method of treatment became rather effective at the treatment of recurrent basal cell skin cancer. photodynamic therapy, basal cell skin cancer, photodynamic therapy, basal cell skin cancer.



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