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by Louis B. Justement,Katherine A. Siminovitch

  • ISBN: 354066002X
  • Category: Math & Science
  • Author: Louis B. Justement,Katherine A. Siminovitch
  • Subcategory: Biological Sciences
  • Other formats: docx lrf doc lit
  • Language: English
  • Publisher: Springer; 2000 edition (September 24, 1999)
  • Pages: 267 pages
  • FB2 size: 1241 kb
  • EPUB size: 1111 kb
  • Rating: 4.7
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Download Signal Transduction and the Coordination of B Lymphocyte Development and Function I: Transduction of BCR Signals from the Cell Membrane to the Nucleus (Current Topics in Microbiology and Immunology) fb2

Current Topics in Microbiology and Immunology Translation of BCR Signals. Katherine A. Siminovitch.

Current Topics in Microbiology and Immunology Translation of BCR Signals. Proper development and differentiation of B lymphocytes is es­ sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep­ ertoire of B cells that has the ability to recognize an almost un­ limited array of foreign antigens. Current Topics in Microbiology and Immunology.

cle{A, title {Signal transduction and the coordination of B lymphocyte .

cle{A, title {Signal transduction and the coordination of B lymphocyte development and function I. Transduction of BCR signals from the cell membrane to the nucleus. Introduction}, author {Justement and Siminovitch}, journal {Current topics in microbiology and immunology}, year {2000}, volume {245 1}, pages {. V-X } }. Justement, Siminovitch. Index Inclusion Reason: No Index Inclusion Reason.

Springer-Verlag Berlin Heidelberg GmbH. Siminovitch Proper development and differentiation of B lymphocytes is essential t. . Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus. With 22 Figures and 5 Tables. Proper development and differentiation of B lymphocytes is essential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens.

Books Medicine & Nursing Basic Sciences Immunology. Books Science & Nature.

Signal Transduction and the Coordination of B Lymphocyte Development and Function I: Transduction of BCR Signals from the Cell Membrane to the Nucleus - Current Topics in Microbiology and Immunology 245/1 (Paperback). The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery.

Signal Transduction and the Coordination of B Lymphocyte Development and Function I.

Signal Transduction and the Coordination of B Lymphocyte Development and Function I : Transduction of BCR Signals from the Cell Membrane to the Nucleus. by Louis B. Justement. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep- ertoire of B cells that has the ability to recognize an almost un- limited array of foreign antigens.

Signal transduction is the term used to describe the flow of information from the cell’s outer membrane through the .

Signal transduction is the term used to describe the flow of information from the cell’s outer membrane through the cytoplasm and into the nucleus. Signals from cell-surface receptors such as GPCRs and growth factor receptors are transduced, either directly or via small G-proteins such as Ras and Rac, to multiple protein kinases that amplify these signals and/or regulate each other. The MAPK module intermediates signal transduction between short life-activated tyrosine-kinase receptors and downstream nuclear signaling.

Topics covered in this part include signal transduction via the pre-B cell antigen receptor complex, the control of immuglobulin gene recombination and allelic exclusion, and molecular regulation of positive and negative selection. These latter chapters present information regarding processes which are critical for the B cell response to foreign antigen that leads to differentiation into antibody secreting plasma. Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg. ISBN-10.

Current Topics in Microbiology and Immmunology. Siminovitch, Katherine . Justement, Louis B. ISBN-13. Assembled Product Dimensions (L x W x H). 1 x . 4 x . 2 Inches.

Blymphocyte development and responses to Ag are regulated by cell surface signaling molecules including the B cell Ag.

Blymphocyte development and responses to Ag are regulated by cell surface signaling molecules including the B cell Ag receptor (BCR). Btk is limiting for transmission of signals from the BCR so B cells with reduced Btk expression or function are hyporesponsive to IgM and other transmembrane signals and generate decreased humoral responses to certain T cell-independent Ags (20, 21).

Proper development and differentiation of B lymphocytes is es­ sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep­ ertoire of B cells that has the ability to recognize an almost un­ limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au­ toreactive B cells to exist in the periphery where they may com­ plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re­ straints that effectively attenuate their ability to respond to self­ antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.

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